WebIn the present study, the effect was investigated of CTCF activity on PAX6 transcription through interaction with five essential motifs located in an 80-bp region upstream from the PAX6 P0 promoter. Methods: An electrophoretic mobility shift assay (EMSA) was used to determine the interaction between CTCF and DNA binding motifs. The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures like the nuclear lamina. It also defines the boundaries between active and heterochromatic DNA. Since the … See more Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs in its structure. CTCF's binding is disrupted by See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease". Trends Genet. 17 (9): 520–7. doi:10.1016/S0168-9525(01)02366-6. PMID 11525835. • Klenova EM, Morse … See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the outcome or if it does so indirectly (in particular through its looping role). Transcriptional … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more

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WebThe user need to give them different names, for example, -–exptCond1 CTCF_cond1.bed -–exptCond2 CTCF_cond2.bed. For multiple replicates of same condition, you can specify multiple replicates as separate files, for … WebCTCF CTCF defines an AnnotationHub resource representing genomic coordinates of FIMO -predicted CTCF binding sites for human and mouse genomes, including the Telomere … the two legs create what type of angle

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WebThat would count any reads with lengths between 36-149, 150-324, and 325-400 from input.bam whose cut points fell in the specified region around motifs from JASPAR2014_CTCF.bed.gz.The cut point counts would be recorded for each fragment size bin, at nucleotide resolution (with no score aggregation in the extended region around … WebNov 28, 2024 · TransEPI: Capturing large genomic contexts for accurately predicting enhancer-promoter interactions. The codes and datasets for Capturing large genomic … WebTier ↓1 Cell Line ↓2 Method ↓3 Track Name ↓4 the two leg bones below the kneecap are