Klf9 function
WebAug 23, 2024 · In the vascular system, KLF activities are regulated at both transcriptional and posttranscriptional levels. Growing in vitro, in vivo, and genetic epidemiology studies suggest that specific KLFs play important roles in vascular wall biology, which further affect vascular diseases. WebTo analyze the function of miR-135a-5p or miR-135b-5p in CRC, SW620 and SW480 cells were transfected with NC mimic, miR-135a-5p or miR-135b-5p mimic for further analysis. ... FOXO1 expression. 29 To probe the downstream target of miR-135a/b-5p in CRC, bioinformatics analysis was performed and KLF9 was predicted as a function target of …
Klf9 function
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WebNov 1, 2024 · In turn, forced expression of KLF9 altered the baseline and GC/E2-responsive expression of several clock genes, indicating that KLF9 may function as a regulator of the core clock machinery. WebOct 27, 2024 · Aims: Krüppel-like Factor 9 (KLF9) is a transcription factor that regulates multiple disease processes. Studies have focused on the role of KLF9 in the redox system. In this study, we aimed to explore the effect of KLF9 on diabetic cardiomyopathy. Methods and Results: Cardiac-specific overexpression or silencing of KLF9 in C57BL/6 J …
WebNov 21, 2014 · Kruppel-like factor-9 (KLF9), a member of the large KLF transcription factor family, has emerged as a regulator of oncogenesis, cell differentiation, and neural development; however, the molecular basis for the diverse contextual functions of KLF9 remains unclear. This study focused on the functions of KLF9 in human glioblastoma … WebSince Klf9 expression occurs predominantly in the pre-receptive stroma, this suggests a role for KLF9 in stromal-epithelial cross-talk important for endometrial receptivity. ... KLF9's function as a molecular brake for BMP2 could be manipulated to advance uterine receptivity in clinical conditions where delayed endometrial maturation may lead ...
WebJun 6, 2024 · Thus, Klf9 functions as a stress-responsive transcription factor that mediates circuit and behavioral resilience in a sex-specific manner. Graphical Abstract. In Brief. Besnard et al. show that chronic stress induces a transient elevation in hippocampal Klf9 expression in mice and that KLF9 expression is upregulated in hippocampus of women …
WebJun 18, 2012 · Klf9 Is a Cortisol-Dependent Marker for Epidermal Differentiation. Among the clock-controlled genes in epidermis a large subset of transcription factors was found that …
WebFeb 23, 2024 · Krüppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis Taken together, our findings support that … is germany muslim countryWebValidation of the Prognostic Value and Immune Function of KFL9 in KIRC. To further clarify the prognostic value of KLF9 in tumor tissues, we used univariate and multivariate Cox regression analyses to further demonstrate that KLF9 could be an independent prognostic factor in KIRC patients. is germany joining bricsWebNov 1, 2024 · The Krüppel-like transcription factor KLF9 enhances oligodendrocyte differentiation in culture, but appears dispensable in vivo. Its mode of action and role … sa156 bobbins where to buyWebJan 4, 2024 · Clonal analysis and longitudinal intravital two-photon imaging directly demonstrate that Klf9 functions as a brake on RGL symmetric self-renewal. In vivo … sa15 department of stateWebBortezomib, a therapeutic agent for multiple myeloma (MM) and mantle cell lymphoma, suppresses proteosomal degradation leading to substantial changes in cellular transcriptional programs and ultimate is germany middle easternWebJan 1, 2024 · KLF9 influences the expression of uterine epithelial genes through mechanisms likely involving its transcriptional activator and repressor functions and … is germany internationalWebApr 13, 2024 · The GSEA function in the clusterProfiler package was used to enrich the GSE38713 expression profile with "c2.cp.kegg.v7.4.symbols.gmt" and "c5.go.bp.v7.4.symbols.gmt" as reference gene sets 30 ... sa185 brother